David C Whitcomb Selected Research

Pancrelipase (Creon)

5/2016	Efficacy and Safety of Pancrelipase/Pancreatin in Patients With Exocrine Pancreatic Insufficiency and a Medical History of Diabetes Mellitus.
4/2011	Pancrelipase delayed-release capsules for the treatment of pancreatic insufficiency.
10/2010	Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trial.

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David C Whitcomb Research Topics

Disease

70	Pancreatitis 01/2022 - 01/2002
47	Chronic Pancreatitis 01/2022 - 01/2002
17	Pancreatic Neoplasms (Pancreatic Cancer) 01/2020 - 09/2004
16	Pain (Aches) 12/2021 - 09/2002
12	Inflammation (Inflammations) 11/2021 - 01/2004
9	Fibrosis (Cirrhosis) 12/2020 - 01/2004
9	Hereditary pancreatitis 01/2020 - 01/2004
9	Neoplasms (Cancer) 11/2019 - 01/2003
8	Diabetes Mellitus 06/2020 - 10/2002
8	Acute Necrotizing Pancreatitis 11/2016 - 02/2006
6	Cystic Fibrosis (Mucoviscidosis) 01/2020 - 01/2005
5	Disease Progression 10/2021 - 10/2006
5	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 10/2021 - 02/2010
5	Pancreatic Diseases (Pancreatic Disease) 01/2020 - 10/2002
5	Necrosis 11/2016 - 02/2006
5	Adenocarcinoma 02/2016 - 12/2006
4	Genetic Predisposition to Disease (Genetic Predisposition) 10/2020 - 10/2002
4	Exocrine Pancreatic Insufficiency 10/2020 - 10/2010
3	Carcinogenesis 01/2020 - 01/2010
3	Abdominal Pain (Pain, Abdominal) 11/2019 - 10/2010
3	Cysts 01/2016 - 10/2005
3	Alcoholic Pancreatitis 09/2012 - 07/2002
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2021 - 11/2011
2	Kidney Diseases (Kidney Disease) 11/2019 - 11/2018
2	Pancreatic Cyst 05/2014 - 10/2005
2	Infections 09/2006 - 01/2002
1	Sepsis (Septicemia) 01/2022
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2022
1	Critical Illness (Critically Ill) 01/2022
1	Wounds and Injuries (Trauma) 01/2022
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2022
1	Ulcerative Colitis 01/2021
1	Intestinal Failure 01/2021
1	Short Bowel Syndrome 01/2021
1	Animal Disease Models 01/2021

Drug/Important Bio-Agent (IBA)

18	Biomarkers (Surrogate Marker)IBA 01/2022 - 08/2008
18	Kazal Pancreatic Trypsin InhibitorIBA 12/2020 - 09/2002
16	TrypsinogenIBA 10/2020 - 09/2002
10	CytokinesIBA 12/2021 - 01/2004
9	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 03/2003
7	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 01/2020 - 09/2002
5	TrypsinIBA 01/2019 - 04/2008
5	Urea (Carbamide)FDA LinkGeneric 08/2016 - 01/2009
5	NitrogenIBA 08/2016 - 01/2009
5	Proteins (Proteins, Gene)FDA Link 05/2016 - 01/2005
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2021 - 03/2003
4	Bicarbonates (Hydrogen Carbonate)IBA 01/2020 - 01/2011
4	CeruletideIBA 10/2017 - 01/2005
3	EnzymesIBA 01/2022 - 07/2002
3	Interleukin-8 (Interleukin 8)IBA 12/2021 - 01/2009
3	Chemokine CCL2 (Monocyte Chemoattractant Protein 1)IBA 12/2021 - 05/2005
3	Opioid Analgesics (Opioids)IBA 10/2020 - 11/2019
3	Analgesics (Analgesic Drugs)IBA 11/2019 - 09/2017
3	Arginine (L-Arginine)FDA Link 01/2019 - 01/2004
3	Biological ProductsIBA 11/2018 - 03/2011
3	Pancrelipase (Creon)FDA Link 05/2016 - 10/2010
3	CreatinineIBA 12/2015 - 01/2009
3	Codon (Codons)IBA 01/2009 - 01/2004
2	NucleotidesIBA 01/2022 - 01/2020
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 04/2014
2	Peptides (Polypeptides)IBA 12/2021 - 01/2005
2	Interleukin-6 (Interleukin 6)IBA 12/2021 - 01/2009
2	Insulin (Novolin)FDA Link 11/2021 - 02/2016
2	RNA (Ribonucleic Acid)IBA 01/2020 - 12/2006
2	AnionsIBA 01/2020 - 01/2016
2	GuanineIBA 01/2020 - 01/2009
2	AntioxidantsIBA 06/2019 - 01/2019
2	Lipase (Acid Lipase)FDA Link 01/2019 - 01/2016
2	Histones (Histone)IBA 01/2019 - 01/2014
2	Pharmaceutical PreparationsIBA 11/2018 - 11/2007
2	Amylases FDA Link 08/2015 - 04/2014
2	chymotrypsinogen CIBA 01/2015 - 01/2010
2	CollagenIBA 11/2013 - 01/2005
2	Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA 01/2010 - 07/2008
2	Calcium-Sensing ReceptorsIBA 01/2010 - 07/2008
2	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 02/2009 - 11/2004
2	Interferon-gamma (Interferon, gamma)IBA 01/2004 - 01/2004
2	Interleukin-10 (Interleukin 10)IBA 01/2004 - 01/2004
1	Chemokine CX3CL1IBA 12/2021
1	ChemokinesIBA 12/2021
1	Interleukin-2 (IL2)IBA 12/2021
1	Substance PIBA 12/2021
1	Interleukin-4 (Interleukin 4)IBA 12/2021
1	Calcitonin Gene-Related PeptideIBA 12/2021
1	Indomethacin (Indometacin)FDA LinkGeneric 10/2021
1	Tuberculin (PPD)IBA 05/2021

Therapy/Procedure

12	Therapeutics 04/2021 - 06/2007
7	Pancreatectomy 11/2021 - 07/2013
4	Autologous Transplantation 11/2021 - 01/2014
4	Precision Medicine 01/2020 - 01/2012
3	Pain Management 12/2021 - 11/2016
3	Resuscitation 06/2017 - 01/2009
2	Cholecystectomy 12/2017 - 01/2002
2	Nutritional Support (Artificial Feeding) 12/2017 - 08/2017
2	Length of Stay 12/2017 - 11/2016
2	Endoscopic Sphincterotomy 09/2016 - 01/2002
2	Sphincterotomy 01/2016 - 05/2014
2	Chemoprevention 01/2016 - 01/2014
1	Home Parenteral Nutrition 01/2021
1	Biological Therapy 01/2021